130EVALUATING THE EXTRA OUTCOMES IN ADDING ZOLEDRONIC ACID YEARLY INFUSION TO CALCIUM VITAMIN D OVER CONVENTIONAL CALCIUM VITAMIN D SUPPLEMENTATION IN TREATING OSTEOPOROSISEvaluate the extra outcomes of adding Zoledronic acid yearly once infusion to Calcium and Vitamin D over the conventional Calcium Vitamin D supplementation in treating osteoporosis. A baseline BMD test is done and the T score was noted initially. Patients were randomized into two groups based on the use of yearly Zoledronic acid infusion along with conventional Calcium and Vitamin D therapy. The patients were followed for the duration of one year to evaluate the patient medication adherence and improvement in bone strength. The second BMD was taken after one year and the change in T score was noted to evaluate the additional benefits of Zoledronic acid regimen over the patients with only Calcium and Vitamin D.The interventions have transformed many patients from osteoporotic to ostiopenic, followed by osteopenic to risk and risk to normal categories. The mean difference for change in T-sore among Hip and Spine was observed as 0.6 and 0.5 respectively in those who treated with Zoledronic acid, only 0.4 and 0.4 was observed in those who treated without Zoleronic acid. This difference in the change in T-score among the two groups is showing the additional benefits of Zoledronic acid yearly once infusion along with Calcium and Vitamin D over the conventional management only with Calcium and Vitamin D. The change in T score from the baseline score has shown the effectiveness of drug therapy. Moreover drug therapy with Zoledronic acid yearly once infusion is showing greater impact and additional benefits on improving the T score as well as bone strength of the patients compare to the patients received only Calcium and Vitamin D..robin.george793@gmail.comResearch922019Additional,Benefits,Zoledronic acid,Conventional,OsteoporosisDr. Sneha K Varghese,Dr. Robin George,Dr.Sindu.J.PunnooraClinical Pharmacist, KIMS Hospital, Thiruvanandapuram - 695029, Kerala, India.,Assistant Professor, Department of Pharmacy Practice, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.,General Physician, K.G. Hospital and Post Graduate Research Institute, Coimbatore, Tamil Nadu. India.